Season
- Season 22 2014-09-02
- Season 21 2014-01-06
- Season 20 2013-01-02
- Season 19 2012-01-03
- Season 18 2011-01-03
- Season 17 2009-08-31
- Season 16 2008-09-02
- Season 15 2007-09-04
- Season 14 2006-08-28
- Season 13 2005-08-29
- Season 12 2004-08-23
- Season 11 2003-09-01
- Season 10 2002-09-03
- Season 9 2001-08-20
- Season 8 2000-08-21
- Season 7 1999-09-07
- Season 6 1998-08-31
- Season 5 1997-09-01
- Season 4 1996-09-02
- Season 3 1995-09-04
- Season 2 1994-08-29
- Season 1 1993-08-30
Episode
- Episode 1: Nicolas Cage, Anna Torv, Terrence Howard
- Episode 2: Dr. Phil McGraw, Tilda Swinton, Tricky
- Episode 3: Robin Williams, Shannen Doherty, Duffy
- Episode 4: John Malkovich, Hayden Panettiere, Steve Earle
- Episode 5: Keira Knightley, Thomas L. Friedman
- Episode 6: Jada Pinkett Smith, Chris Russo, Michael Buble
- Episode 7: Sen. Barack Obama, LeBron James
- Episode 8: Jessica Simpson, Jack Hanna
- Episode 9: Meg Ryan, Ricky Gervais
- Episode 10: Bill Clinton, Chris Rock
- Episode 11: Julianne Moore, Tom Dreesen & Tim Reid, Kings of Leon
- Episode 12: Keith Olbermann, Chandra Wilson, Delta Goodrem
- Episode 13: Paris Hilton, Usain Bolt, Morningwood
- Episode 14: Lance Armstrong, Kristen Wiig, TV on the Radio
- Episode 15: Julia Louis-Dreyfus, Michael Cera, Pete Seeger
- Episode 16: Anne Hathaway, Josette Sheeran, The Virgins
- Episode 17: Kate Walsh, Barry Sonnenfeld, Darius Rucker
- Episode 18: Calista Flockhart, Bill Hader, Lucinda Williams
- Episode 19: Brian Williams, Tim Robbins
- Episode 20: Russell Crowe, Sarah Vowell, The Pretenders
- Episode 21: Debra Messing, John Carter, Tegan & Sara
- Episode 22: Dennis Quaid, Sarah Chalke, Buddy Guy
- Episode 23: Bill Murray, Beck
- Episode 24: Jeremy Piven, Elizabeth Banks, Lou Reed
- Episode 25: Sarah Silverman, the Teutuls, Ra Ra Riot
- Episode 26: Josh Brolin, Amy Sedaris, Blues Traveler
- Episode 27: Martin Short, Marv Albert
- Episode 28: Sen. John McCain, Ne-Yo
- Episode 29: Tina Fey, Frank Caliendo, Tim Montana
- Episode 30: Bill O'Reilly, Lauren Conrad
- Episode 31: Regis Philbin, James Taylor
- Episode 32: Alec Baldwin, Paul Mooney, Ryan Adams
- Episode 33: Ashley Olsen, Paul Rudd, John Legend
- Episode 34: Marcia Cross, Alan Zweibel
- Episode 35: Paris Hilton, Elvis Costello, Jenny Lewis, a Top Ten List by Ricky Gervais
- Episode 36: Tom Brokaw, Vera Farmiga
- Episode 37: Ben Stiller, Q-Tip
- Episode 38: Natalie Portman, Artie Lange, Brad Paisley
- Episode 39: Ted Turner, Jamie Oliver, Taylor Swift
- Episode 40: Don Rickles, Amy Brenneman, Alicia Keys
- Episode 41: Russell Brand, Charlie Haden
- Episode 42: Bruce Willis, Sia
- Episode 43: Bill Cosby, Matt Braunger
- Episode 44: Emma Thompson, Michelle Felicetta, Purple Reign
- Episode 45: Carla Bruni Sarkozy, Jack Hanna, Cold Hard Cash
- Episode 46: Katie Couric, Dev Patel, Mr. Brownstone
- Episode 47: Stephen Colbert, Kristen Stewart, Super Diamond
- Episode 48: James Franco, Bruce McCall, The Allstarz
- Episode 49: Nicole Kidman, Simon Baker, Kanye West
- Episode 50: Reese Witherspoon, Harry Connick Jr.
- Episode 51: Teri Hatcher, Ludacris
- Episode 52: Denis Leary, John Mayer
- Episode 53: Tom Arnold, Faith Hill
- Episode 54: Jennifer Connelly, Anderson Cooper, The Duke Spirit
- Episode 55: Amy Adams, Michael Sheen, Jamey Johnson
- Episode 56: Keanu Reeves, Paula Abdul, Loudon Wainwright III
- Episode 57: Sen. John McCain, Bon Iver
- Episode 58: Meryl Streep, Jeff Altman
- Episode 59: Adam Sandler
- Episode 60: Tom Cruise, Fall Out Boy
- Episode 61: Jennifer Aniston, Broken Social Scene
- Episode 62: Will Smith, Of Montreal
- Episode 63: Jerry Seinfeld, Leona Lewis
- Episode 64: Dustin Hoffman, Todd Rundgren
- Episode 65: Jay Thomas, Mickey Rourke, Darlene Love
- Episode 66: Tracy Morgan, Matt Braunger
- Episode 67: Kate Hudson, Glasvegas
- Episode 68: Kevin James, Becky Quick, Erin McCarley
- Episode 69: Ricky Gervais, Rose Byrne, Okkervil River
- Episode 70: Kate Winslet, Marv Albert
- Episode 71: Kiefer Sutherland, Wendy Liebman
- Episode 72: Billy Crystal, Kara DioGuardi
- Episode 73: Salma Hayek, Jimmie Walker
- Episode 74: Clint Eastwood, Randy Rogers Band
- Episode 75: Kyra Sedgwick, Gwen Ifill
- Episode 76: Zach Braff, Arj Barker, The Airborne Toxic Event
- Episode 77: Brian Williams, Ben Kweller
- Episode 78: Evangeline Lilly, Seth Meyers, Andrew Bird
- Episode 79: Lauren Graham, Guy Fieri, MENEW
- Episode 80: Renee Zellweger, Tony Dungy, Graham Nash sits in with the band
- Episode 81: Mary Hicks, the Gaslight Anthem
- Episode 82: Ben Roethlisberger, Steve Martin
- Episode 83: Rod Blagojevich, Richard Jenkins
- Episode 84: Joe Torre, Demetri Martin, Lyle Lovett and John Hiatt
- Episode 85: Isla Fisher, extreme fisherman Matt Watson, Mark Olson and Gary Louris, a Top Ten List presented by Lil' Wayne
- Episode 86: Dakota Fanning, Keith Alberstadt, Beirut
- Episode 87: Naomi Watts, Danny McBride, 2009 Sports Illustrated Swimsuit Issue cover reveal
- Episode 88: The crew of US Airways "Miracle On The Hudson" Flight 1549, Heartless Bastards
- Episode 89: Joaquin Phoenix, Bar Refaeli, Anthony Hamilton
- Episode 90: Chris Russo, the Jonas Brothers, Ashford & Simpson
- Episode 91: Martha Stewart, Jake Johannsen, Matt Nathanson
- Episode 92: Ellen Pompeo, Daytona 500 winner Matt Kenseth, Willie Nelson with Asleep at the Wheel
- Episode 93: Bonnie Hunt, M. Ward
- Episode 94: Donald Trump, Antony and the Johnsons
- Episode 95: David Spade, Jeffrey Sachs, David Sanborn with Sam Moore
- Episode 96: Barbara Walters, Mike Birbiglia, Shemekia Copeland
- Episode 97: Katie Couric, U2
- Episode 98: Felicity Huffman, Artie Lange, U2
- Episode 99: Dr. Phil McGraw, U2
- Episode 100: Jon Stewart, U2, a Top Ten List featuring 10 Team USA members from the World Baseball Classic
- Episode 101: Jason Segel, Brian Kiley, U2
- Episode 102: Russell Brand, Jack Hanna
- Episode 103: Stupid Pet Tricks, Paul Rudd, Razorlight
- Episode 104: Tom Brokaw, An Horse
- Episode 105: Andy Samberg, Paul Teutul Sr., the Broadway cast of "West Side Story"
- Episode 106: Will Ferrell, Cursive
- Episode 107: Nicolas Cage, Rachel Maddow
- Episode 108: Julia Roberts, Bell X1
- Episode 109: Craig Ferguson, Ginnifer Goodwin, Modest Mouse
- Episode 110: Billy Crystal, Kara DioGuardi, a Top Ten List presented by Owen Wilson
- Episode 111: David Spade, Richard Zoglin, David Sanborn and Sam Moore
- Episode 112: Hugh Laurie, Bloc Party
- Episode 113: Mary Tyler Moore, Blake Lively, White Lies
- Episode 114: Christina Applegate, Jim Gaffigan, Jesse Harris with Norah Jones
- Episode 115: Seth Rogen, Tom Dreesen, Adele
- Episode 116: Bill O'Reilly, Marianne Faithfull
- Episode 117: Marg Helgenberger, Francisco Palacios, Ray LaMontagne
- Episode 118: Michael J. Fox, the Fray
- Episode 119: Denis Leary, Diana Krall
- Episode 120: Zac Efron, Mike Golic and Mike Greenberg, A.C. Newman with Nicole Atkins
- Episode 121: Kelly Ripa, Bill Scheft, Yeah Yeah Yeahs
- Episode 122: Drew Barrymore, Jack McBrayer, Neko Case
- Episode 123: Matthew Perry, Elisha Cuthbert, Rascal Flatts
- Episode 124: Russell Crowe, Joe Wong
- Episode 125: Jeff Goldblum, Jeff Dunham
- Episode 126: Nathan Lane, Tinted Windows
- Episode 127: Beyonce, Jim Parsons
- Episode 128: Jamie Foxx, Lauren Conrad, the Dead
- Episode 129: Michael Keaton, Lily Allen
- Episode 130: Matthew Fox, Carol Leifer, the All-American Rejects, a Top Ten List presented by Matthew Stafford
- Episode 131: Dolly Parton, Zachary Quinto
- Episode 132: Jennifer Garner, Tesla Motors CEO Elon Musk, Manchester Orchestra
- Episode 133: Regis Philbin, a performance by the Broadway cast of "Hair"
- Episode 134: Kiefer Sutherland, Jim Norton, Bat for Lashes
- Episode 135: Gordon Ramsay, Chris Pine, Keri Hilson with Kanye West
- Episode 136: Liev Schreiber, Dr. Sanjay Gupta, Franz Ferdinand
- Episode 137: Bruce Willis, Ben Harper & Relentless7
- Episode 138: Norm MacDonald, a Top Ten List presented by Leonard Nimoy, Animal Collective
- Episode 139: Matthew Broderick, Brian Regan, Chris Cornell
- Episode 140: Tom Hanks, the Killers
- Episode 141: Alec Baldwin, Maya Rudolph, Chrisette Michele
- Episode 142: Robin Williams, Wynton Marsalis
- Episode 143: Kid Scientists, Teri Hatcher, Rick Ross with Magazeen, a Top Ten List presented by Ron Howard
- Episode 144: John Goodman, Tommy Tiernan, Mastodon
- Episode 145: Ben Stiller, White Rabbits
- Episode 146: Jane Fonda, Piedmont Bird Callers, Kenny Chesney
- Episode 147: Stephen Colbert, General Motors Vice Chairman Bob Lutz, Grizzly Bear
- Episode 148: Amy Sedaris, Ed Helms, Jean Redpath
- Episode 149: Ricky Gervais, Green Day
- Episode 150: Bill Cosby, Helio Castroneves, Melody Gardot
- Episode 151: Jack Hanna, John Krasinski
- Episode 152: Jessica Biel, Zach Galifianakis, Steve Earle
- Episode 153: Elvis Costello, a Top Ten List presented by Neil Patrick Harris
- Episode 154: Paris Hilton, Calvin Borel, Steven Wright
- Episode 155: Howard Stern, Mos Def
- Episode 156: Julia Roberts, Black Eyed Peas
- Episode 157: Kathy Griffin, Stupid Human Tricks, Sonic Youth, an NBA Finals report by Phoenix Suns' Steve Nash
- Episode 158: Denzel Washington, the Jonas Brothers, a Top Ten List with Regis Philbin
- Episode 159: Sandra Bullock, Pete Correale, P.J. Harvey & John Parish
- Episode 160: Jack Black, M.A. Sanjayan
- Episode 161: Michelle Pfeiffer, Judah Friedlander, Ian McLagan & the Bump Band
- Episode 162: Ryan Reynolds, Padma Lakshmi, the Eels
- Episode 163: Danny DeVito, Bear Grylls, Phoenix
- Episode 164: Jada Pinkett Smith, Michael Cera, the Sounds
- Episode 165: Samuel L. Jackson, Emeril Lagasse, Iggy Pop & the Brighton Port Authority
- Episode 166: Sandra Day O'Connor, MSTRKRFT with John Legend, a Top Ten List presented by Lucas Glover
- Episode 167: Ray Romano, St. Vincent
- Episode 168: Johnny Depp, Megan Fox
- Episode 169: Martin Short, Regina Spektor
- Episode 170: Serena Williams, Hayden Panettiere, Conor Oberst and the Mystic Valley Band
- Episode 171: Sacha Baron Cohen, Joel McHale
- Episode 172: Queen Latifah, Emma Watson
- Episode 173: Daniel Radcliffe, Veronika Part, Levon Helm, a Top Ten List presented by Bruno
- Episode 174: Rainn Wilson, Larry Miller, Maxwell
- Episode 175: Jonah Hill, Gar Ryness, Kelly Clarkson
- Episode 176: Edie Falco, Michael Showalter, Wilco with Feist
- Episode 177: Paul McCartney, a Top Ten List presented by Bruce Willis
- Episode 178: Anderson Cooper, Anna Paquin, Grizzly Bear
- Episode 179: Tom Arnold, Metric, a Top Ten List presented by Dave's mom Dorothy
- Episode 180: Katherine Heigl, Jeff Altman, Spinnerette
- Episode 181: Kevin Spacey, Jesse James, the Flatlanders, a Top Ten List presented by Stewart Cink
- Episode 182: Tracy Morgan, Leslie Mann, Diane Birch
- Episode 183: Sean "Diddy" Combs, Vera Farmiga, Ginuwine with Missy Elliott
- Episode 184: Amy Poehler, Nick Griffin, Judy Collins
- Episode 185: Eric Bana, Dave Matthews Band, a Top Ten List presented by Chicago White Sox star Mark Buehrle
- Episode 186: Katie Couric, Silversun Pickups
- Episode 187: Amy Adams, Tom Dreesen, Elbow
- Episode 188: Adam Sandler, Cage the Elephant
- Episode 189: Regis Philbin, Ted Alexandro, Dave Matthews Band
- Episode 190: Quentin Tarantino, Eric Ripert, Robert Cray
- Episode 191: Donald Trump, Diane Kruger, Billy Currington, a Top Ten List presented by Britney Spears
- Episode 192: Mike Myers, Ken Burns
- Episode 193: Anna Wintour, Mark Teixeira
- Episode 194: Renee Zellweger, Gary Mule Deer
- Episode 195: Christina Applegate, Brendan Benson, Patton Oswalt
- Episode 196: Anna Wintour, Mark Teixeira
- Episode 197: Mary-Louise Parker, Eugene Levy, Jet
- Episode 198: Anne Heche, Jim Parsons, Care Bears on Fire
- Episode 199: Andy Roddick, Rachael Ray, Mutemath
- Episode 200: Artie Lange, Todd Barry, Imogen Heap
Late Show with David Letterman Season 16 Serena Williams, Hayden Panettiere, Conor Oberst and the Mystic Valley Band
David Letterman uses mature humor to appeal to his audience in this weeknight series, which gets its music from a house band led by Paul Shaffer. Among the show's most-famous segments are the Top Ten List and Stupid Pet Tricks, the latter of which subsequently led to an additional recurring segment called Stupid Human Tricks.
